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KMID : 0379520010170040287
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한국독성학회지
2001 Volume.17 No. 4 p.287 ~ p.296
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Acute Oral Toxicity Test in Japanese Quail
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Choi Eun-Sil
Park Jong-Hwan
Hong Jung-Joo
Park Jae-Hak
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Abstract
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The acute oral LD5O toxicity values of isazofos, pyraclofos, diazinon and methomyl were determined for Japanese quail based on OECD guideline. The LD_{50} of isazofos, pyraclofos and diazinon was 16.26 mg/kg, and 7.11mg/kg body weight In female respectively. And the LD_{50} of each chemical in male was 21.44, 35.64, 8.28 mg/kg body weight respectively. Diazinon was the most susceptible compounds to Japanese quail in both sexes. The LD_{50} of methomyl was 21.24 mg/kg body weights in female, and 28.28 mg/kg body weight in male respectively. Diazinon, isazofos and methomyl were more toxic In the female than male. The symptoms of poisoning were similar in quails administrated with each chemicals. The clinical sign in Japanese quail were ataxia, salivation, diarrhea, ruffled feather and convulsion at dead point. There were severe hemorrhage and catarrhal inflammation from duodenum to ileum In all compounds. In Japanese quail treated with organophosphorus and carbamate compounds, brain acetylcholinesterase was inhibited by 88-96. The recovery was not observed after 5 h in sublethal dose.
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KEYWORD
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Acute oral toxicity test, Japanese quail, Organophosphate compounds, Carbamate comppound, Acetylcholinesterase
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